Homework Assignment 1997 - 2 (Answers)

Problem 3

kelnormal = 0.45 hr-1

fenormal = 0.55

Thus: kenormal = 0.45 x 0.55 = 0.25 hr-1

and kmnormal = 0.45 - 0.25 = 0.20 hr-1

Now kerenal patient = kenormal/5 = 0.25/5 = 0.05 hr-1

and kmrenal patient = kmnormal = 0.20 hr-1

kelrenal patient = 0.05 + 0.20 = 0.25 hr-1

t1/2 went from 1.54 hr to 2.75 hr

Summary

Parameter

Value

Unit

kerenal patient

0.05

hr-1

kelrenal patient

0.25

hr-1