PHAR 4634 - Chapter 6 Page 1

VI Intravenous Infusion

Objectives:

=> To draw the scheme and write the differential equations for a one compartment pharmacokinetic model after IV. infusion administration
=> To recognize and use the integrated equation for drug concentrations during and after an IV. infusion administration
=> To calculate kel and V from IV. infusion data

=> To design and calculate appropriate IV. infusion (IV. infusion alone, fast/slow IV. infusion, or infusion/bolus) dosage regimens

Commonly in a hospital setting a patient will receive a drug by intravenous infusion. The inconvenience of administering the drug over a long time is not a real problem with bedridden patients. Some may already be receiving intravenous fluids. If a drug is chemically stable and is compatible with the intravenous fluid it may be added to the fluid and thereby be given by slow infusion.

Some drugs cannot be given by rapid intravenous injection. Therefore they may be given by slower IV infusion over 15 or 30 minutes.

This page was last modified: 12 February 2001