==> To calculate appropriate multiple dose drug regimen
==> To define, use, and calculate the parameter
So far we have looked at multiple IV bolus administration. In an analogous fashion, equations can be developed which enable you to calculate the plasma concentration achieved following multiple oral administration. To start the plasma concentration achieved following a single oral dose can be given by:-
Equation XV-1 Cp after a Single Oral Dose
This can be converted to an equation describing plasma concentration at any time following n equal doses with constant dosing interval t.
Equation XV-2, General Equation
Figure XV-1, Plot of Cp Versus Time for Multiple Oral Doses showing Cpmax and Cpmin
Plasma Concentration versus Time Plots
The Cpmax value can be calculated at the time t = tpeak after many doses (n -> ) but it is complicated by the need to determine the value for tpeak.
Copyright 2001 David W.A. Bourne