=> To understand the effect of protein binding on drug distribution and methods by which protein binding is measured
Drug distribution means the reversible transfer of drug from one location to another within the body. Once a drug has entered the vascular system it becomes distributed throughout the various tissues and body fluids in a pattern that reflects the physiochemical nature of the drug and the ease with which it penetrates different membranes. The ONE COMPARTMENT model assumes rapid distribution but it does not preclude extensive distribution into various tissues.
Copyright 2001 David W.A. Bourne