Homework #6 1995 Answer #6

MRT(I.V.) = AUMC(iv)/AUC(iv) = 519.34/73.91 = 7.03 hr

MRT(P.O.) = AUMC(po)/AUC(po) = 937.89/116.74 = 8.03 hr

MAT (P.O.) = MRT(po) - MRT(iv) = 8.034 - 7.03 = 1.01 hr

kel' = 1/MRT(iv) = 1/7.03 = 0.142 hr-1 [Assuming one compartment model, etc.]

ka' = 1/MAT(po) = 1/1.007 = 0.993 hr-1 [Assuming first order absorption]

CL(I.V.) = Dose/AUC(iv) = 150/73.91 = 2.03 L/hr

Vss(I.V.) = CL(iv) x MRT(iv) = 2.03 x 7.03 = 14.3 L

F(P.O.) = (AUC(po) x Dose(iv))/(AUC(iv) x Dose(po)) = (116.74 x 150) / (73.91 x 300) = 0.79