Q 2.1 Mathematical models are defined with the ADAPT program using FORTRAN, a computer language.

TRUE

Q 2.2 Detectors used for quantitation with the GLC method include electron capture and flame ionization.

TRUE

Q 2.3 The finger print method for back transforming Laplace transforms requires the numerator have a lower power in 's' than the denominator.

TRUE

Q 2.4 SAAM II can be used to calculate concentration versus time data using given parameter values or to find best values for parameters.

TRUE Just like Boomer, WinNonlin, and ADAPT

Q 2.5 For a given IV bolus dose, the larger the value of the apparent volume of distribution the larger will be the initial plasma concentration.

FALSE

Q 2.6 Appropriate units for AUC are mg.hr.L^-1.

TRUE

Q 2.7 If elimination from the central/body compartment is first order we can assume that a one compartment pharmacokinetic model is applicable.

FALSE Each assumption is independent

Q 2.8 Mathematical models are defined in WinNONLIN by selecting model parameters from a selection of parameter types.

FALSE WinNONLIN uses a library of complete models (or a computer language)