PHAR 7633 Fall 1999

Q 2.1 Version A.Q 2.6 Version D. If you notice a 'U' shape in the weighted residual versus time plot this usually suggests that the model chosen is too small and more parameters may be needed

Q 2.1 Version B, C. If you notice a 'U' shape in the weighted residual versus time plot this usually suggests that the model chosen is too large and fewer parameters may be needed

Q 2.2 Version A, D. Facilitated membrane transport of a drug can move drug from low to high concentrations more quickly because of the involvement of a drug carrier.

Q 2.2 Version B. Q 2.6 Version C. Facilitated membrane transport of a drug can move drug from high to low concentrations more quickly because of the involvement of a drug carrier.

Q 2.3 Version A, B. Q 2.8 Version C. Q 2.7 Version D. Enteric coated tablets are designed to resist dissolution in the stomach since some drugs are not stable in low pH solutions.

Q 2.4 Version A, D. The value of tmax observed after oral administration is independent of F and ka.

Q 2.4 Version B. Q 2.7 Version C. The value of tmax observed after oral administration is dependent on the values of F and ka.

Q 2.5 Version A. Q 2.8 Version D. The integrated equation of the form A = B * [1 - e^-C*t], is consistent with plasma concentrations during an IV infusion.

Q 2.5 Version B, C. The integrated equation of the form A = B * e^-C*t, is consistent with plasma concentrations during an IV infusion.

Q 2.6 Version A, B. Q 2.2 Version C. Q 2.1 Version D. Buccal absorption is a good route of administration, especially if the dose is small and the drug is extensively metabolized. That is, it would be subjected to an extreme first-pass effect if taken orally.

Q 2.7 Version A. Q 2.3 Version D. Appropriate units for k0 are mg.hr.

Q 2.7 Version B. Q 2.4 Version C. Appropriate units for k0 are mg/hr.

Q 2.8 Version A, B. Q 2.3 Version C. Q 2.5 Version D.An identifiable parameter is one that both influences the value of calculated data and can be readily estimate from the data provided