PHAR 7633 Fall 1999

Pharmacokinetics

OU HSC College of Pharmacy

Second Exam 12 November 1999

Section ONE Sketch a Graph or Diagram&emdash;Sketch the graphs or diagrams requested in the space provided. Make sure you carefully include any distinguishing characteristics and include labels andunits for all graph axes. Assume that a linear one-compartment model applies for each sketch when appropriate. 5 x 4 = 20 points

Q 1.1 Version A. A linear plot of Cp versus time after four equal multiple IV bolus doses given at intervals equal to the drug elimination half-life.

Q 1.1 Version B, D. A semi-log plot of Cp versus time after four equal multiple IV bolus doses given at intervals equal to the drug elimination half-life.

Q 1.1 Version C. A linear plot of Cp versus time after four equal multiple oral doses given at intervals equal to the drug elimination half-life.

Q1.2 Version A. A Dettli plot for a drug with fe = 0.25.

Q1.2 Version B. A Dettli plot for a drug with fe = 0.75.

Q1.2 Version C. A Dettli plot for a drug with fe = 0.0.

Q1.2 Version D. A Dettli plot for a drug with fe = 1.0.

Q1.3 Version A, C, D. A Scatchard plot representing 1:1 drug protein binding with one type of binding site.

Q1.3 Version B. Q1.4 Version D. Draw a diagram representing enterohepatic recycling and label three components..

Q1.4 Version A, D. Q1.5 Version B. Sketch a nephron and label three components

Q1.4 Version B. Sketch an equilbrium dialysis experiment for protein binding determination and label the components.

Q1.4 Version C. Sketch an ultrafiltration experiment for protein binding determination and label the components.

Q1.5 Version A, C. Sketch a linear plot of Cp versus time after a single oral dose illustrating enterohepatic recycling.


This file was last modified:
Copyright 1999 David W.A. Bourne