Fitting Plasma and Heart Rate Data with SAAM II

It is possible to fit multiple data sets or lines with SAAM II just as with Boomer. You can also write equations for parts of the model to be included in the model. Thus the Hill equation can be included in the model.

The model drawn for a two compartment pharmacokinetic model. s1 is drug concentration and s2 will be heart rate with the receptor residing in the second compartment.

The dialog box for s1.
Note the Associate with Data Name is Cp.

The dialog box for s2.
Note the Associate with Data Name is Hr. Note also the equation defined for s2 = Base+(Emax*q2^slope/(EC50+q2^slope))

The information in the Data Window looks like:

DATA
(FSD 0.1)
t Cp
          0.25	         20.19
          0.50	         15.71
          1.00	         12.91
          1.50	          9.93
          2.00	          9.19
          3.00	          6.59
          4.00	          6.03
          6.00	          4.71
          9.00	          3.19
         12.00	          2.18
         15.00	          1.70
END
DATA
(SD 2.5)
t HR
          0.00	         65.17
          0.25	         75.05
          0.50	         89.47
          1.00	        100.70
          2.00	         93.75
          3.00	         96.12
          4.00	         89.83
          6.00	         86.64
          9.00	         83.76
         12.00	         76.00
         18.00	         67.94
         24.00	         70.58
         30.00	         62.90
         36.00	         63.27
         48.00	         59.29
END
Notice that the table headings are t Cp and t HR matching the Data Names defined above for Cp and HR. Also notice that different weighting schemes or value are possible.