Chapter 11

Physiological Factors Affecting Oral Absorption

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Physiological factors affecting oral absorption

Student Objectives for this Chapter

After completing the material in this chapter each student should:- In the next few Chapters physiological, physical-chemical, and formulation factors which can influence the observed rate and extent of oral absorption will be discussed.

Looking briefly at the overall picture of drug absorption, distribution, and elimination.

Figure 11.1.1 Diagram Representing Absorption, Distribution, Metabolism and Excretion

The ultimate goal is to have the drug reach the site of action in a concentration which produces a pharmacological effect. No matter how the drug is given (other than IV) it must pass through a number of biological membranes before it reaches the site of action.

We can start by looking at:

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