** FINAL OUTPUT FROM Boomer (v3.3.0) **       8 September 2006 --- 12:58:25 pm

 Title:  Fit to data before and after termination of an IV infusion  
 Input: From Fig2202.BAT                                                     
 Output:  To Fig2202.OUT                                                     
 Data for [Drug]          came from keyboard (or ?.BAT)                                             
 Fitting algorithm: Simplex Method             
 Weighting for [Drug]          by 1/Cp(Obs )^2                                      
 Numerical integration method: 2) Fehlberg RKF45                          
          with  1 de(s)
 With relative error   0.1000E-03
 With absolute error   0.1000E-03
 PC =   0.1000E-04

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) kel                   0.91411E-01                        0.0       1.0    
  2) V                      13.473                            1.0      0.10E+03

 Final WSS =   0.886382E-01  R^2 =   0.9671     Corr. Coeff =   0.9834    
 AIC =   -17.8087            AICc =   -15.8087    
 Log likelihood =   8.02     Schwartz Criteria =   -17.4143    
 R^2 and R - jp1     0.9714        0.9856    
 R^2 and R - jp2     0.9714        0.9856    
 RMSE =     0.6363     or          9.924 % RMSE
 MAE  =     0.5252     ME =    -0.2553E-01

 ** FINAL OUTPUT FROM Boomer (v3.3.0) **       8 September 2006 --- 12:58:25 pm

 Title:  Fit to data before and after termination of an IV infusion  
 Input: From Fig2202.BAT                                                     
 Output:  To Fig2202.OUT                                                     
 Data for [Drug]          came from keyboard (or ?.BAT)                                             
 Fitting algorithm: DAMPING-GAUSS/SIMPLEX      
 Weighting for [Drug]          by 1/Cp(Obs )^2                                      
 Numerical integration method: 2) Fehlberg RKF45                          
          with  1 de(s)
 With relative error   0.1000E-03
 With absolute error   0.1000E-03
 DT =   0.1000E-02     PC =   0.1000E-04 Loops =     1
 Damping =     1

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) kel                   0.91394E-01  0.431E-02   4.7       0.0       1.0    
  2) V                      13.473      0.618       4.6       1.0      0.10E+03

 Final WSS =   0.886379E-01  R^2 =   0.9671     Corr. Coeff =   0.9834    
 AIC =   -17.8088            AICc =   -15.8088    
 Log likelihood =   8.02     Schwartz Criteria =   -17.4143    
 R^2 and R - jp1     0.9714        0.9856    
 R^2 and R - jp2     0.9714        0.9856    
 RMSE =     0.6363     or          9.924 % RMSE
 MAE  =     0.5253     ME =    -0.2487E-01

 Model and Parameter Definition

  #  Name                    Value       Type From To     Dep  Start Stop

  1) kel                 =  0.9139E-01    2    1    0       0    0    0
  2) V                   =   13.47       18    1    1       0    0    0
  3) Duration            =   2.000        0    0    0       0    0    0
  4) k0                  =   100.0        3    0    1       0    0    1

 Data for [Drug]          :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2   0.5000       3.80000       3.62768      0.263158      0.453483E-01
     3    1.000       7.40000       7.09331      0.135135      0.414446E-01
     4    1.500       10.8000       10.4041      0.925926E-01  0.366539E-01
     5    2.000       0.00000       13.5671       0.00000       0.00000    
     6    3.000       12.0000       12.3821      0.833333E-01 -0.318423E-01
     7    5.000       9.00000       10.3136      0.111111     -0.145958    
     8    9.000       8.00000       7.15555      0.125000      0.105556    
     9    12.00       5.00000       5.43961      0.200000     -0.879214E-01
    10    18.00       3.90000       3.14352      0.256410      0.193968    
    11    24.00       1.70000       1.81663      0.588235     -0.686045E-01

 WSS data set  1 =   0.8864E-01R^2 =   0.9671     Corr. Coeff. =   0.9834    
 R^2 and R - jp1     0.9714        0.9856    
 R^2 and R - jp2     0.9714        0.9856    
 RMSE =     0.6363     or          9.924 % RMSE
 MAE  =     0.5253     ME =    -0.2487E-01

 Maximum value for [Drug]          is      12.000     at       3.000    

 Calculation of AUC and AUMC based on trapezoidal rule

 AUC and AUMC for [Drug]          using Observed data

       Time         Concentration      AUC             AUMC

      0.00000    (     0.00000    )
     0.500000          3.80000        0.950000        0.475000    
      1.00000          7.40000         3.75000         2.80000    
      1.50000          10.8000         8.30000         8.70000    
      2.00000          0.00000         11.0000         12.7500    
      3.00000          12.0000         17.0000         30.7500    
      5.00000          9.00000         38.0000         111.750    
      9.00000          8.00000         72.0000         345.750    
      12.0000          5.00000         91.5000         543.750    
      18.0000          3.90000         118.200         934.350    
      24.0000          1.70000         135.000         1267.35    
                                       153.601         1917.29    

 Secondary Parameters

MRT =      12.482    

 Half-life values for each first order rate constant

   Parameter   1 has a half-life of kel is       7.58    

 Dose/AUC (= Clearance/F)

   Parameter   4 gives k0/AUC (CL/F) of     -0.651    

 Calculation of AUC and AUMC using Method 9 of R.D. Purves

 AUC and AUMC for [Drug]          using Observed data

       Time         Concentration      AUC             AUMC

      0.00000    (     0.00000    )
     0.500000          3.80000    
      1.00000          7.40000         3.76667         2.50000    
      1.50000          10.8000         8.32500         8.26875    
      2.00000          0.00000         11.3250         13.2938    
      3.00000          12.0000         16.6583         27.6271    
      5.00000          9.00000         37.5147         110.054    
      9.00000          8.00000         71.4754         346.446    
      12.0000          5.00000         90.6242         545.267    
      18.0000          3.90000         117.188         940.422    
      24.0000          1.70000         133.085         1267.73    
                                       151.685         1917.68    

 Secondary Parameters

MRT =      12.642    

 Half-life values for each first order rate constant

   Parameter   1 has a half-life of kel is       7.58    

 Dose/AUC (= Clearance/F)

   Parameter   4 gives k0/AUC (CL/F) of     -0.659    

      Plots of observed (*) and calculated values (+)
           versus time for [Drug]         . Superimposed points (X)

    13.57      Linear                      13.57      Semi-log
 |   +                                   |   +                                 
 |                                       |                                     
 |                                       |    X                                
 |    +                                  |                                     
 |    *                                  |  X    +                             
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 |  X                                    |                                     
 |       +                               |             *                       
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 |       *                               |                                     
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 |             *                         |                                     
 | *                                     |                  +                  
 | +           +                         |                  *                  
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 |                  +                    |                                     
 |                  *                    |*                          *         
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 |X                          *           |                           +         
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 |X  *                                   |                                    X
 |_____________________________________  |X__*_________________________________
    0.000                                  1.700    
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Drug]                versus log(calc Cp(i)) for [Drug]         

    1.955                                  1.955    
 |                           X           |         X                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |             X                         |                        X            
 |                                       |                                     
 |X                                      |            X                        
 | XX                                    |                        X      X     
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 0X==X=================================  0====================================X
 |    X                                  |                                  X  
 |                                       |                                     
 |                                    X  |X                                    
 |                  X                    |                   X                 
 |                                       |                                     
 |       X                               |                               X     
 |                                       |                                     
   -1.471                                 -1.471    
      0.0       <-->             24.          1.8       <-->             14.