Pharmacokinetics and Biopharmaceutics
Advanced Course

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Basic Pharmacokinetics
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Course Description

Pharmacokinetics and Biopharmaceutics

Advanced Material

Basic Pharmacokinetics and Biopharmaceutics

Course Objectives

Students will be able to:

Instructor: David W.A. Bourne, B.Pharm., Ph.D.

E-mail Address

Related Resources

The websites p4, p1, p3, and pkin should be useful.

References text - see the online list of pharmacokinetic text

Course Outline

  1. Online Resources
  2. Background Mathematical Material
  3. Biopharmaceutics and Pharmacokinetic Introduction

  4. Modeling
    Program Set-Up
    Program Output

  5. One Compartment IV Bolus
  6. Analysis of Urine Data
  7. Intravenous Infusion
  8. Routes of Drug Administration
  9. Pharmacokinetics of Oral Administration
  10. Calculation of Bioavailability Parameters
  11. Bioavailability Studies
  12. Analytical Integration - Integrating Differential Equations using Laplace Tranforms
    Numerical integration
    Weighting Schemes

  13. Physiological Factors Affecting Oral Absorption
  14. Physical-Chemical Factors Affecting Oral Absorption
  15. Formulation Factors
  16. Selection of the "best" model

  17. Multiple IV Bolus Dose Administration
  18. Multiple Oral Dose Administration
  19. Routes of Excretion
  20. Metabolism
  21. Drug Distribution
  22. Multi-Compartment Pharmacokinetic Models
  23. Noncompartmental Analysis
  24. Non-Linear Pharmacokinetic Models
  25. Non-Linear Regression Analysis of Pharmacokinetic Data
  26. Identifiability
  27. Pharmacodynamic and Physiologically Based Pharmacokinetic Models
  28. Pharmaceutical Analysis
  29. Clinical Applications of Pharmacokinetics
  30. Optimal sampling
    Bayesian analysis and population modeling


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