Pharmacokinetics and Biopharmaceutics
Advanced Course
This website: https://www.boomer.org/c/p4/
The eBook: Basic Pharmacokinetics and other eBooks for the iPad^{®}
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Course Description
Pharmacokinetics and Biopharmaceutics
Advanced Material
Development of pharmacokinetic equations using Laplace transforms. Modeling pharmacokinetic data using computer programs such as Boomer.
Basic Pharmacokinetics and Biopharmaceutics
Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.
Application of biopharmaceutical and pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients
Course Objectives
Students will be able to:
- Demonstrate an understanding of the differential and integrated equations associated with pharmacokinetic models
- Derive integrated equations associated with pharmacokinetic models
- Model pharmacokinetic data using computer programs such as Boomer
- Demonstrate an understanding and assess factors which affect the absorption, distribution, metabolism and excretion of drugs
- Calculate parameter values from appropriate data using graphical and computer techniques
- Calculate appropriate dosing regimens using appropriate criteria
- Describe the techniques used to determine drug concentrations in biological and formulation matrices
Instructor: David W.A. Bourne, B.Pharm., Ph.D.
E-mail Address
Related Resources
The websites p4 and PharmPK should be useful.
References text - see the online list of pharmacokinetic text
Course Outline
- Online Resources
- Background Mathematical Material
- Biopharmaceutics and Pharmacokinetic Introduction
Modeling
Program Set-Up
Program Output
- One Compartment IV Bolus
- Analysis of Urine Data
- Intravenous Infusion
- Routes of Drug Administration
- Pharmacokinetics of Oral Administration
- Calculation of Bioavailability Parameters
- Bioavailability Studies
Analytical Integration - Integrating Differential Equations using Laplace Tranforms
Numerical integration
Optimization
Weighting Schemes
- Physiological Factors Affecting Oral Absorption
- Physical-Chemical Factors Affecting Oral Absorption
- Formulation Factors
Selection of the "best" model
- Multiple IV Bolus Dose Administration
- Multiple Oral Dose Administration
- Routes of Excretion
- Metabolism
- Drug Distribution
- Multi-Compartment Pharmacokinetic Models
- Noncompartmental Analysis
- Non-Linear Pharmacokinetic Models
- Non-Linear Regression Analysis of Pharmacokinetic Data
Identifiability
Optimal sampling
Bayesian Analysis
Population Pharmacokinetic (PopPK) Modeling
- Pharmacodynamic and Physiologically Based Pharmacokinetic Models
- Pharmaceutical Analysis
- Clinical Applications of Pharmacokinetics
Assignments
This page was last modified: Wednesday, 7th Apr 2021 at 5:45 pm
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