Explore the relationship between extraction ratio, blood flow, clearance, volume and elimination half-life. The hepatic (E(H)) and renal (E(R)) extration ratios may be varied between 0 and 100%. The apparent volume of distribution for different drugs may vary from a low of about 10 L up to 1000 L or more. The interrelationship between these parameters influence the overall elimination of a drug.
The derivation of these relationships include extraction ratio, clearance, elimination rate constant and half-life.
Equation 4.3.1 Hepatic Extration Ratio
Equation 4.3.2 Renal Extration Ratio
Equation 4.3.3 Hepatic Clearance
Equation 4.3.4 Renal Clearance
Equation 4.3.5 Total Body Clearance
Equation 4.3.6 Elimination Rate Constant
Equation 4.3.7 Elimination Half-life
Adjust the Extraction Ratio(s) and apparent Volume of Distribution to explore these relationships.