Chapter 2 - Page 8 - Figure 5

Calculation of the Area Under the Curve
Trapezoidal Rule

Try out the calculator by pressing Random Data or entering your own data. Plot the data on the semi-log plot. Select or deselect data to get a good value for the terminal slope, kel, using the graph and R² value. Select all the data and press Calculate to determine the AUC. The last segment is calculated using the last data point and the value of kel. If the expected initial concentration is zero replace the value at the top of the table, as shown above, otherwise use the calculated extrapolated value determined when Plot is pressed. Dose/AUC may be clearance if after an IV bolus or CL/F if after an extravascular, e.g. oral, dose.

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Chapter 2 - Page 8 - Figure 5

Calculation of the Area Under the CurveTrapezoidal Rule

Calculation of the Area Under the Curve
Trapezoidal Rule