Calculation of Drug Concentration

Uniform Multiple IV Bolus Dose Regimen

A patient is started on a drug at an IV bolus dose of 100 mg every 24 hours. Calculate the drug concentration at a few of time points during the first three dosing interval. Specifically calculate the concentration three hours after the first dose, two hours after the second dose and one hour after the third dose. Assume a one compartment linear model applies to this drug in this concentration range. The Clearance and V for this drug in this patient (55.2 kg) are 5.4 L/hr and 0.4 L/kg, respectively.

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The equation:

Cp after multiple IV bolus doses

Equation 25.2.1 Drug Concentration, Cp, after Multiple IV Bolus Doses (Uniform Dosing Interval and Dose)

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