Question 2. A drug was given by multiple oral doses of 25 mg every 6 hr. Assume a one compartment linear model applies to this drug in this concentration range. For this dosage form and patient the bioavailability is 0.8 and the absorption rate constant is 2.34 hr

Question 3. A drug has been given by multiple oral dose of 75 mg every 6 hours. Assume a one compartment linear model applies to this drug in this concentration range. The half-life and V for this drug in this patient (100.9 kg) are 5.2 hr and 0.4 L/kg, respectively. For this dosage form and patient the bioavailability is 0.81 and the absorption rate constant is 2.69 hr

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**Equation 26.1.1 Minimum Drug Concentration at Steady State after Multiple Oral Doses**

If e^{-ka • τ} approaches zero

**Equation 26.1.2 Minimum Drug Concentration at Steady State after Multiple Oral Doses**

If ka >> kel then ka/(ka-kel) approaches 1.

**Equation 26.1.3 Minimum Drug Concentration at Steady State after Multiple Oral Doses**

Estimate, very approximately, Cp_{max}

**Equation 26.1.4 Approximate value of Cp _{max}**

**Equation 26.1.5 Average Drug Concentration, Cp(bar)**

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