Question 2. A drug was given by multiple oral doses of 100 mg every 8 hr. Assume a one compartment linear model applies to this drug in this concentration range. For this dosage form and patient the bioavailability is 0.91 and the absorption rate constant is 1.65 hr

Question 3. A drug has been given by multiple oral dose of 50 mg every 8 hours. Assume a one compartment linear model applies to this drug in this concentration range. The half-life and V for this drug in this patient are 4.1 hr and 36.5 L, respectively. For this dosage form and patient the bioavailability is 0.9 and the absorption rate constant is 1.57 hr

will prevent you getting credit for this problem

You will have one chance to submit your answers for this problem [# 2592116400]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.

**Equation 26.1.1 Minimum Drug Concentration at Steady State after Multiple Oral Doses**

If e^{-ka • τ} approaches zero

**Equation 26.1.2 Minimum Drug Concentration at Steady State after Multiple Oral Doses**

If ka >> kel then ka/(ka-kel) approaches 1.

**Equation 26.1.3 Minimum Drug Concentration at Steady State after Multiple Oral Doses**

Estimate, very approximately, Cp_{max}

**Equation 26.1.4 Approximate value of Cp _{max}**

**Equation 26.1.5 Average Drug Concentration, Cp(bar)**

Last update: Sat 31 Aug 2019 10:12:57 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available