|Age: 57 yr||Gender: female||Weight: 64.5 kg||ht: 69 in|
|Scr: 2.23 mg/dL||Organism MIC 0.5 mg/L|
Based on the following doses and serum concentrations, calculate the following: kel, t1/2, Vd, CL, infusion dose (down to the nearest 10 mg) over 1 hr, dosing interval (up to the nearest 12 hr), projected Cpmaxss and Cpminss with target Cpmaxss = 8 mg/L and Cpminss = less than 1 mg/L.
|Date||Time||Dosage||Infusion Duration||Serum Concentration|
|09/17/15||2200||300 mg||1 hr|
|09/18/15||1000||300 mg||1 hr|
|09/18/15||2200||300 mg||1 hr|
|09/19/15||1000||300 mg||1 hr|
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Equation 27.4.2 IBW for Female Patients
Equation 27.4.3 Creatinine Clearance (Cockcroft-Gault Equation)
Equation 27.4.4 Apparent Volume of Distribution, Vd
Equation 27.4.5 Dosing Interval, τ
Equation 27.4.6 Loading Dose
Equation 27.4.7 Maintenance Dose