Age: 84 yr | Gender: male | Weight: 50.5 kg | ht: 70 in |
Scr: 1.59 mg/dL | Organism MIC 0.5 mg/L |
Based on the following doses and serum concentrations, calculate the following: kel, t1/2, Vd, CL, infusion dose (down to the nearest 10 mg) over 1 hr, dosing interval (up to the nearest 12 hr), projected Cpmaxss and Cpminss with target Cpmaxss = 8 mg/L and Cpminss = less than 1 mg/L.
Date | Time | Dosage | Infusion Duration | Serum Concentration |
---|---|---|---|---|
09/17/15 | 2200 | 80 mg | 1 hr | |
09/18/15 | 1000 | 80 mg | 1 hr | |
09/18/15 | 2200 | 80 mg | 1 hr | |
09/19/15 | 0950 | 3.54 mg/L | ||
09/19/15 | 1000 | 80 mg | 1 hr | |
09/19/15 | 1230 | 10.46 mg/L | ||
09/19/15 | 2130 | 4.42 mg/L |
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Equation 27.4.2 IBW for Female Patients
Equation 27.4.3 Creatinine Clearance (Cockcroft-Gault Equation)
Equation 27.4.4 Apparent Volume of Distribution, Vd
Equation 27.4.5 Dosing Interval, τ
Equation 27.4.6 Loading Dose
Equation 27.4.7 Maintenance Dose
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