Simulation of Drug Concentration
Two Compartment Model
A patient is to receive lidocaine by IV bolus (three doses possible) and a continuous IV infusion to achieve and maintain drug concentrations between 2 and 6 mg/L for 120 minutes. For this patient use parameters value of kel, k12, k21 and V1 of 0.0249 min-1, 0.0862 min-1, 0.0404 min-1, and 34.1 L, respectively.
Equation 30.5.1 Loading Dose using V1
Equation 30.5.2 Maintenance Infusion Rate using V1 or Clearance
Equation 30.5.3 Drug Concentration after an IV Bolus Dose
Equation 30.5.4 Drug Concentration after an IV continuous Infusion
Version (a) was derived from the Laplace prepared by convolution with roots 0, -α and β. Version (b) was derived by rearranging version (a). In version (c) clearance, CL, replaces V1 • kel.
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