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Question 1. Determine an intravenous loading dose of phenytoin sodium injection for JY, 6'0", 92 Kg male, using a volume of distribution of 0.65 L/Kg and a desired level of 22 mg/L. Round to the nearest multiple of 50 mg. (1 point)
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Question 2. Determine a daily maintenance dose of oral phenytoin sodium capsules for JY using a Vmax of 8.05 mg/kg/day, Km of 4.2 mg/L, Css = 15.6 mg/L. Round to the nearest dose using available phenytoin sodium capsules to determine a daily dose for JY. (1 point)
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Question 3. A 21 year-old, 5'7", 84 kg female had been receiving 250 mg phenytoin chewable tablets daily for 2 weeks and her trough plasma concentration was 7.92 mg/L. Her dose was increased to 200 mg twice a day and now two weeks later her phenytoin level is 26.8 mg/L. (3 x 0.5 points)
a. Calculate the patient-specific Km.
b. Calculate the patient-specific Vmax
c. Calculate the new maintenance daily dose of phenytoin chewable tablets with a desired Cpss of 21 mg/L using both patient-specific Vmax and Km.
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