PharmPC Discussion - HPLC of Cystatin-C

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On 30 Nov 2000 at 12:00:27, Kazimierz (khkoz.at.czd.waw.pl) sent the message


From: Kazimierz H. Kozlowski, Pharm. D.
           Laboratory of Clinical Pharmacology
           The Children's Memorial Health Institute
           04-736 Warsaw, POLAND
           E-mail: khkoz.at.czd.waw.pl

Dear PharmPC Group,

Does anyone have any experience or concept for HPLC determination of
Cystatin-C serum level?

Cystatin-C is small protein, currently considered as endogenous
biomarker of glomerular filtration rate.
The laser nephelometric methods are very expensive and require
additional instrument and kits.
Above biomarker I consider as covariate for pharmacokinetics of drugs
possessed kidney clearance.
                                                           sincerely

Kazimierz H. Kozlowski

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