PharmPC Discussion - Serotonin and analogs /agonist stability in tissue culture.

• On 3 Mar 2000 at 22:02:11, jbmed.at.hotmail.com sent the message
  

  
  Hi,
  Does anybody know or have experience with serotonin/ serotonin
  analogs or agonist in tissue culture?
  Serotonin is a very unstable compound (under physiological conditions).
  I am looking for an analog/agonist or precursor that is more stable
  in tissue culture media.
  Does anybody have any suggestions?
  I am looking at these compounds for the moment:
  5-carboxamidotryptamine maleate(agonist)
  2-methyl-5-hydroxytriptamine hydrochloride( agonist)
  alpha-methyl-5-hydroxytriptamine maleate.(agonist)
  I thank you for your attention to this matter.
  Judith
  
  

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• On 5 Mar 2000 at 22:20:17, stef (ser3.at.duke.edu) sent the message
  

  
  Are you talking about instability in solution or instability due to
  metabolism?
  To protect against metabolism, include enzyme inhibitors (this is standard
  in in vitro studies of transport-- you can find favored compounds and
  concentrations in the literature).
  
  Stef Renick
  
  

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• On 6 Mar 2000 at 20:53:36, "" (jbmed.at.hotmail.com) sent the message
  

  
  Hi,
  Thank you for your quick response.
  My problem is instability of serotonin in solution.
  I need a compound/analog, agonist of serotonin that is stable in solution.
  I am not doing metabolic studies.
  Thank you again
  JB
  
  

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David Bourne (david@boomer.org)