PharmPC Discussion - What is in rat plasma?

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On 21 Apr 2000 at 21:25:28, Chandrani Gunaratna (prema.at.bioanalytical.com) sent the message


To the group,

We are assaying a compound in rat, human and dog plasma (plasma spiked with
the compound). In dog and human plasma the compound elutes as a nice single
peak. However, in rat plasma another peak appears just before the compound
peak. It seems that adding ascorbic acid reverses that to a single peak
indicating an oxidation in rat plasma. Does anybody know of any
information/reference regarding the composition differences in the plasma
of different animal species?

Thank you all for your response.

Chandrani Gunaratna

Chandrani Gunaratna, Ph.D.
Senior Research Scientist
Bioanalytical Systems
2701 Kent Avenue
West Lafayette, IN 47906
Phone: (765)463-4527
E-Mail: prema.at.bioanalytical.com

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