PharmPC Discussion - Isoniazid Stability in Plasma

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On 13 Nov 1995 at 11:51:24, Colin Pillai (cpillai.at.pixie.udw.ac.za) sent the message


We are presently developing an HPLC assay for isoniazid and AcINH (in
plasma) in our  laboratory but are having difficulty with inter-day
reproducibility of results.

Other authors have reported a problem with the stability of INH and its
acetyl derivative and we therefore store all samples in  cryotubes in a
cooler box with dry-ice  (solid carbon dioxide).  We do
not have a -70 freezer.

Is there anyone out there that is available to discuss this with us and
make suggestions as to what we are doing wrong?

Thanks

Colin Pillai
Department of Pharmacology
University of Durban-Westville
Private Bag X54001
DURBAN, South Africa

from: Colin Pillai

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