PharmPC Discussion - Solubilisation of Triclosan

• On 13 Nov 1996 at 11:38:40, "Hr Dr. S. Shapiro" (toukie.at.zui.unizh.ch) sent the message
  

  
  Dear Colleagues;
  
       We are presently faced with a problem with which I hope someone in this
  group may be able to help.
  
       The compound Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a
  widely-used antimicrobial agent.  For some studies we wish to perform we'd like
  to have a 0.2% solution of this compound.  However, this compound is rather
  insoluble in water and in 10% polyethylene glycol.  We have tried dissolving in
  in ethanol (it is freely soluble in this alcohol), but when we dilute it with
  water the Triclosan comes out of solution.
  
       I am soliciting suggestions as to how I might be able to prepare a 0.2%
  aqueous solution of Triclosan, using non-toxic (or relatively non-toxic) solu-
  bilisng agents.  If anyone has any suggestions, kindly contact me directly
  at
  
                                 toukie.at.zui.unizh.ch
  
       Thanks in advance to all responders.
  
  Sincerely,
  
  S. Shapiro
  ZH, CH
  toukie.at.zui.unizh.ch
  
  

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• On 14 Nov 1996 at 12:47:37, Prasad Tata (Prasadt.at.OTSUKA.OAPI.COM) sent the message
  

  
       We are presently faced with a problem with which I hope
  someone in
  this group may be able to help.
  
       The compound Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl
  ether) is
  a widely-used antimicrobial agent.  For some studies we wish
  to perform
  we'd like to have a 0.2% solution of this compound.  However,
  this
  compound is rather insoluble in water and in 10% polyethylene
  glycol.
  We have tried dissolving in in ethanol (it is freely soluble in this
  alcohol),
  but when we dilute it with water the Triclosan comes out of
  solution.
  
  You can try a cosolubilization of your drug with the help of a combination
  of Tween 80 (0.3%), and 10% propylene glycol and the remaining
  vehicle can be water.
  
  You have to first stirr your drug  with ~ 0.3 % W/V Tween 80 (or
  Cremopher EL-20 from BASF) and mix with propylene glycol to form a
  uniform solution. Add this solution as a thin streem under continuous
  stirring in to the aqeous vehicle. In many cases this technique worked
  and hope this works for you if you need further help do not hesitate to
  contact me.
  
  Prasad Tata, Ph.D.
       I am soliciting suggestions as to how I might be able to prepare a 0.2%
  aqueous solution of Triclosan, using non-toxic (or relatively non-toxic)
  solu- bilisng agents.  If anyone has any suggestions, kindly contact me
  directly at
  
                                 toukie.at.zui.unizh.ch
  
       Thanks in advance to all responders.
  
  Sincerely,
  
  S. Shapiro
  ZH, CH toukie.at.zui.unizh.ch
  
  

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David Bourne (david@boomer.org)