PharmPC Discussion - Solubilisation of Triclosan

• On 20 Nov 1996 at 12:03:36, Bob Behme (behme.at.evansville.net) sent the message
  

  
  Solubilization of insoluble compounds is interesting and frustrating.
  Have done a lot of work in the past for Bristol Myers Squibb for
  insoluble drugs using hydrotropic solubilization.  Essentially this is
  adding compounds like niacimamide that are highly soluble in water and
  alter the properties of water.  I would be interested in testing
  Triclosan with hydrotropic solubilizing agents.
  
  Bob Behme
  
  

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• On 21 Nov 1996 at 10:51:34, Madhu Vodapalli (sudhan.at.uconnvm.uconn.edu) sent the message
  

  
  At 12:03 PM 11/20/96 -0600, you wrote:
  >Have done a lot of work in the past for Bristol Myers Squibb for
  >insoluble drugs using hydrotropic solubilization.
  >Bob Behme
  
  A similar method would use excipients like sucrose and mannitol
  to increase the solubility of the drug using a solvent deposition
  technique.  I used it for Nitrofurantoin with good results during
  my Master's dissertation work.
  
  Madhu Vodapalli (sudhan.at.uconnvm.uconn.edu)
  School of Pharmacy
  Univ. of Connecticut
  Storrs, CT 06268
  Ph: (860) 486-5052
  
  

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David Bourne (david@boomer.org)