PharmPC Discussion - Information on pKa and LogP of SSRIs

• On 8 Jan 1998 at 09:44:34, John Kim (johnk.at.unixg.ubc.ca) sent the message
  

  
  Dear colleagues,
  Do you know any source where I could find information of pKa and partition
  coefficient of selective serotonin reuptake inhibitors? I have tried to
  find these information on fluoxetine, paroxetine and sertraline from
  different places but with limited success.  I have logP of fluoxetine and
  paroxetine from Hans et al. ("Big Red Book" of medicinal chemistry) but
  not the other info. I would greatly appreciate any help or suggestion on
  this matter. Thank you very much.
  John Kim
  Faculty of Pharmaceutical Sciences
  University of British Columbia
  Vancouver, B
  from johnk.at.unixg.ubc.ca
  
  from: John Kim 
  
  

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• On 9 Jan 1998 at 11:26:30, Richard Prankerd (richard.prankerd.at.pharmacy.uq.edu.au) sent the message
  

  
  John:
  
  A quick search of available resources has not yielded any measured values
  for the compounds listed. However, they are all secondary aliphatic amines,
  and could be expected to have pKa values in the range 10.0 to 11.2. The
  attached substituents might give values at the lower end of the range
  rather than the upper end.
  
  Regards
  Richard
  
  Richard J. Prankerd, PhD
  Senior Lecturer
  School of Pharmacy
  University of Queensland        Phone: INT + (617) 3365-3179
  St Lucia QLD 4072               Fax: INT + (617) 3365-1688
  AUSTRALIA               richard.at.uqpharmacy.pharmacy.uq.edu.au
                          http://www.uq.edu.au/pharmacy/academic.html
  
  

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David Bourne (david@boomer.org)