PharmPC Discussion - Theophylline Binding to Serum Proteins

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On 27 Jun 1999 at 22:37:12, Wayne Mullett (wmullett.at.ccs.carleton.ca) sent the message


Dear PharmPC,

Is theophylline bound to proteins found in blood serum?  If so, would it
remain bound to these proteins after a liquid extraction with chloroform
was performed or would the chloroform layer now only contain the free
portion of theophylline?

Thank you in advance,

Wayne Mullett
wmullett.at.ccs.carlteon.ca

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On 28 Jun 1999 at 20:16:01, "Daniel C. Leggett" (dleggett.at.crrel.usace.army.mil) sent the message


My guess is that it is only weakly bound and will all extract with
chloroform, but I would do a serial extraction/analysis anyway to determine
recovery efficiency of each extraction from the aqueous protein phase.
D. Leggett

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