A First Course in Pharmacokinetics and Biopharmaceutics

• 1. Introduction to Course
  • Staff
  • Grading
  • Coursework
  • Laboratory Experiments
  • Textbook
  • Other References
  • Journals
• 2. Background Material
  • Exponents
  • Logarithms
    • Semi-log graph paper
  • Calculus
    • Differential Calculus
    • Integral Calculus
  • Spreadsheet Calculations
  • Spectrophotometric Analysis
• 3. Pharmacokinetic Introduction
• 4. One Compartment I.V. Bolus
  • Assumptions
  • First-order kinetics
  • Plasma data
  • Area under the Curve
  • Half-life
• 5. Analysis of Urine Data
  • Excretion Unchanged - No Metabolism
  • Metabolism and Excretion - Parallel Pathways
  • Clearance, CL
• 6. Intravenous Infusion
  • Continuous infusion - steady state
  • Combined Infusion and bolus administration
  • Combined slow and fast infusion
  • Post infusion
• 7. Routes of Drug Administration
  • Oral
  • Buccal/Sublingual
  • Rectal
  • Intravenous
  • Subcutaneous
  • Intramuscular
  • Inhalation
  • Topical
  • Other ROA's
• 8. Pharmacokinetics of Oral Administration
  • Differential equation
  • Integrated equation
  • Absorption rate constant, ka
  • Extent of absorption
• 9. Calculation of Bioavailability Parameters
  • Calculation of ka
  • Calculation of F
• 10. Bioavailability Studies
  • Definitions
  • Past bioavailability problems
  • Reasons for bioequivalence requirements
  • Bioavailability study characteristics
• 11. Physiological Factors Affecting Oral Absorption
  • Membrane physiology
  • Gastrointestinal physiology
• 12. Physical-Chemical Factors Affecting Oral Absorption
  • pH - partition
  • Drug dissolution
• 13. Formulation Factors
  • Solutions
  • Suspensions
  • Capsules
  • Tablets
  • Sustained release tablets
  • In vitro dosage form testing
• 14. Multiple IV Bolus Dose Administration
  • Single dose summary
    • IV bolus
    • IV infusion
    • Oral administration
  • Multiple IV bolus
    • Independent doses
    • Accumulating doses
    • Development of general equation
    • Cpmax and Cpmin equations
• 15. Multiple Oral Dose Administration
  • Cpmin equation
  • Average Cp equation
  • Non-uniform dosing intervals
• 16. Routes of Excretion
  • Renal excretion
  • Hemodialysis
  • Biliary excretion
  • Pulmonary excretion
  • Salivary excretion
  • Renal disease considerations
    • Dose adjustment
    • Average Cp calculations
    • Cpmax/Cpmin calculations
• 17. Metabolism
  • Metabolic reactions
    • Phase I
    • Phase II
  • Induction
  • Inhibition
  • Hepatic clearance
  • Systemic availability
• 18. Drug Distribution
  • Drug distribution patterns
  • Factors affecting drug distribution
    • Rate of distribution
    • Extent of distribution
  • Weight considerations
  • Protein binding interactions
• 19. Multi-Compartment Pharmacokinetic Models
  • Intravenous administration
    • Scheme or diagram
    • Differential equation
    • Integrated equation
    • Parameter determination
    • Effect of k12 and k21
    • Apparent volumes of distribution
    • Dosage calculations
  • Oral administration
  • Non Compartmental Analysis
• 20. Non-Linear Pharmacokinetic Models
  • Scheme or diagram
  • Differential equation
  • Parallel pathway
  • Dosing approaches
• 21. Clinical Applications of Pharmacokinetics
  • Therapeutic drug monitoring
  • Pediatric considerations
  • Geriatric considerations
• 22. Laboratory Assignments
  • Introduction
  • Analysis of drugs by visible spectroscopy
  • Extraction of salicylic acid
  • One compartment model - IV bolus
  • One compartment model - IV infusion
  • One compartment model - Oral
  • Computer simulation - single dose
  • Student presentation concerning Biopharmaceutics
  • One compartment model-IV bolus- multiple dose
  • Computer simulation - multiple dose
  • Computer simulation - two compartment models
  • Student presentations on Pharmacokinetics
  • Pharmacokinetic simulations using MacDope

Exams and Homework Sets (with answers)

Exams (1995)

• First Exam
• Second Exam
• Final Exam

Homework Sets (1995)

• Chapter 4
• Chapter 5
• Chapter 6
• Chapter 8
• Chapter 15
• Chapter 20

Homework Sets (1997)

• Chapter 4
• Chapter 5
• Chapter 19
• Chapter 20

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