IV Infusion - Example Calculations

During an IV Infusion - Linear One Compartment Model

Question 1. Calculate the drug concentration 24 hours after a continuous IV infusion of 10 mg/hr has been administered to a patient. Assume a one compartment pharmacokinetic model. The kel and V values for this drug are 0.148 hr^-1 and 26.4 L respectively.

Question 2. Calculate the infusion rate required to achieve a drug concentration of 2 mg/L at 2 hours after a continuous IV infusion has been started. Assume a one compartment pharmacokinetic model. The V and t_1/2 values for this drug are 38 L and 3.5 hr respectively.

Question 3. Calculate the steady state drug concentration after a continuous IV infusion of 50 mg/hr has been administered to the patient. Assume a one compartment pharmacokinetic model. The kel and V values for this drug are 0.354 hr^-1 and 41.3 L respectively.

Question 4. Calculate the infusion rate required to achieve a steady state drug concentration of 24 mg/L. Assume a one compartment pharmacokinetic model. The V and total body clearance values for this drug are 47.5 L and 9.8 L/hr respectively.

NOTE: Clicking the button above
will prevent you getting credit for this problem

To get credit for this problem print this page, work the problem and

You will have one chance to submit your answers for this problem [# 371402296]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.

Some Equations:

Equation 15.1.1 Drug Concentration during an IV Infusion

Cp after a continuous IV Infusion

Equation 15.1.2 Steady State Drug Concentration after an IV Infusion

Last update: Thu 19 Jan 2012 09:10:04 am

Practice problem answers may not be available on occasion. These practice problems may be used for graded homework from time to time. For any given problem set this will probably be for one or two weeks at most. Please try later.