IV Infusion - Example Calculations

During an IV Infusion - Linear One Compartment Model

Question 1. Calculate the drug concentration 0.5 hours after a continuous IV infusion of 6 mg/hr has been administered to a patient. Assume a one compartment pharmacokinetic model. The V and t_1/2 values for this drug are 42.6 L and 3.7 hr respectively.

Question 2. Calculate the infusion rate required to achieve a drug concentration of 18 mg/L at 12 hours after a continuous IV infusion has been started. Assume a one compartment pharmacokinetic model. The V and total body clearance values for this drug are 48.1 L and 9 L/hr respectively.

Question 3. Calculate the steady state drug concentration after a continuous IV infusion of 12.5 mg/hr has been administered to the patient. Assume a one compartment pharmacokinetic model. The V and t_1/2 values for this drug are 42.3 L and 2.3 hr respectively.

Question 4. Calculate the infusion rate required to achieve a steady state drug concentration of 2 mg/L. Assume a one compartment pharmacokinetic model. The V and t_1/2 values for this drug are 43.2 L and 4.3 hr respectively.

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Some Equations:

Equation 15.1.1 Drug Concentration during an IV Infusion

Cp after a continuous IV Infusion

Equation 15.1.2 Steady State Drug Concentration after an IV Infusion

Last update: Mon 27 Feb 2006 12:38:30 pm

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