Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 100 mg was 105.9 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 41.6 L and 0.1056 hr^-1. After an oral capsule dose (B) of 25 mg the calculated AUC was 100.9 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 40.44 L and 0.0989 hr^-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2. The AUC calculated after an oral tablet (A) of 75 mg was 107.8 mg.hr/L. After an oral capsule dose (B) of 250 mg the calculated AUC was 257.2 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.68 calculate the absolute bioavailability of the tablet dosage form.

Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 125 mg was 66.1 mg. After an oral capsule dose (B) of 25 mg the U^∞ was 13.8 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.71 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U^∞ Values

Last update: Tue 1 Apr 2008 11:20:58 am

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