Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 100 mg was 53.9 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 44.53 L and 0.1001 hr^-1. After an oral capsule dose (B) of 150 mg the calculated AUC was 73.5 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 44.57 L and 0.1189 hr^-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2. The AUC calculated after an oral tablet (A) of 250 mg was 107.5 mg.hr/L. After an oral capsule dose (B) of 25 mg the calculated AUC was 14 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 1 calculate the absolute bioavailability of the tablet dosage form.

Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 25 mg was 16.8 mg. After an oral capsule dose (B) of 75 mg the U^∞ was 65 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.98 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U^∞ Values

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