Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 25 mg was 140.3 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 36.29 L and 0.0968 hr^-1. After an oral capsule dose (B) of 75 mg the calculated AUC was 86.8 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 34.92 L and 0.088 hr^-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2. The AUC calculated after an oral tablet (A) of 150 mg was 89.7 mg.hr/L. After an oral capsule dose (B) of 100 mg the calculated AUC was 51.1 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.76 calculate the absolute bioavailability of the tablet dosage form.

Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 25 mg was 15 mg. After an oral capsule dose (B) of 125 mg the U^∞ was 104.6 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.99 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U^∞ Values

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