Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 25 mg was 83.9 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 54.54 L and 0.2614 hr^-1. After an oral capsule dose (B) of 250 mg the calculated AUC was 119.9 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 55.98 L and 0.2171 hr^-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2. The AUC calculated after an oral tablet (A) of 150 mg was 80 mg.hr/L. After an oral capsule dose (B) of 125 mg the calculated AUC was 48.5 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.72 calculate the absolute bioavailability of the tablet dosage form.

Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 150 mg was 129 mg. After an oral capsule dose (B) of 25 mg the U^∞ was 22.5 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.9 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U^∞ Values

Last update: Tue 1 Apr 2008 11:20:58 am

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