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Calculation of Drug Concentration

Non-Uniform Multiple IV Bolus Dose Regimen

A patient is started on a drug at an IV bolus dose of 25 mg at time zero, 75 mg at 6 hours and 75 mg at 30 hours (makes no sense but a nice random regimen :- all times are from time zero). Calculate the drug concentration at a few of time points during the first three dosing interval. Graph these data on semi-log graph paper (The graph is not required for this homework exercise). Specifically calculate the concentration three hours after the first dose, two hours after the second dose and one hour after the third dose. Assume a one compartment linear model applies to this drug in this concentration range. The half-life and V for this drug in this patient (69.4 kg) are 3.3 hr and 0.64 L/kg, respectively.

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The equation:

Equation 25.5.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Tue 27 Dec 2005 02:39:08 pm

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