Calculation of Drug Concentration

Non-Uniform Multiple IV Bolus Dose Regimen

A patient is started on a drug at an IV bolus dose of 125 mg at time zero, 125 mg at 4 hours and 200 mg at 16 hours (makes no sense but a nice random regimen :- all times are from time zero). Calculate the drug concentration at a few of time points during the first three dosing interval. Graph these data on semi-log graph paper (The graph is not required for this homework exercise). Specifically calculate the concentration three hours after the first dose, two hours after the second dose and one hour after the third dose. Assume a one compartment linear model applies to this drug in this concentration range. The kel and V for this drug in this patient (80 kg) are 0.06 hr and 0.2 L/kg, respectively.

Want to try another data set? Click this button.

The equation:

Equation 25.5.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Wed 23 Feb 2011 01:22:53 pm

Practice problem answers may not be available on occasion. These practice problems may be used for graded homework from time to time. For any given problem set this will probably be for one or two weeks at most. Please try later.