Multiple IV Bolus - Example Calculations 1

Question 1. A potent drug is to be given by multiple IV bolus injections. On consideration of the patient's clinical condition it is decided that drug concentrations should be maintained between 9 and 2 mg/L. Assume a one compartment linear model applies to this drug in this concentration range. The half-life and V for this drug in this patient are 3 hr and 41.7 L, respectively. Calculate the dosing interval that will exactly achieve this concentration requirement. Round this dosing interval to the nearest, appropriate multiple of 2 hour. Recalculate the fraction remaining at the end of the dosing interval (R') and estimate an appropriate loading and maintenance dose (rounding to the nearest appropriate 10 mg). Finally, check your answer by estimating Cpmax and Cpmin.

NOTE: Clicking the button above
will prevent you getting credit for this problem

To get credit for this problem print this page, work the problem and

You will have one chance to submit your answers for this problem [# 2942252565]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.


The Equations:

Cp after multiple doses

Equation 25.1.1 Drug Concentration during a Multiple Dose Regimen (Uniform Regimen)

Cp during at Multiple Dose at Steady State

Equation 25.1.2 Steady State Drug Concentrations after Multiple Dose Regimen (Uniform Regimen)

Accumulation factor, R

Equation 25.1.3 Fraction Remaining at the End of the Dosing Interval, R

Loading and Maintenance IV Bolus Dose

Equation 25.1.4 Loading and Maintenance IV Dose

Cp after non uniform multiple dose regimen

Equation 25.1.5 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)


Last update: Mon 26 Mar 2012 09:22:55 am
Copyright © 2002-14 David Bourne (david@boomer.org)