Multiple IV Bolus - Example Calculations 3

Question 3. A potent drug has been given by multiple IV bolus dose of 200 mg every 12 hours. Assume a one compartment linear model applies to this drug in this concentration range. The half-life and V for this drug in this patient (105.8 kg) are 3.6 hr and 0.3 L/kg, respectively. Calculate the expected Cp_max and Cp_min values at steady state.

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The Equations:

Equation 25.1.1 Drug Concentration during a Multiple Dose Regimen (Uniform Regimen)

Cp during at Multiple Dose at Steady State

Equation 25.1.2 Steady State Drug Concentrations after Multiple Dose Regimen (Uniform Regimen)

Accumulation factor, R

Equation 25.1.3 Accumulation Factor, R

Loading and Maintenance IV Bolus Dose

Equation 25.1.4 Loading and Maintenance IV Dose

Cp after non uniform multiple dose regimen

Equation 25.1.5 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Mon 27 Feb 2006 12:45:49 pm

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