Two compartment IV Bolus - Example Calculations

Micro to Macro Constants

Question 1. A drug follows first order (i.e. linear) two compartment pharmacokinetics. After looking in the literature we find a number of parameter values for this drug. These numbers represent the micro constants for this drug. In order that we can calculate the drug concentration after a single IV bolus dose these parameters need to be converted into values for the macro constants. The Clearance and V1 for this drug in this patient are 6 L/hr and 43.9 L, respectively. The k12 and k21 values this drug are 1.27 and 1.7 hr^-1, respectively. What is the plasma concentration of this drug 3 hours after a 50 mg, IV Bolus dose. In order to complete this calculation first calculate the appropriate A, B, α and β values.

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Some Equations:

Equation 30.1.1 Cp versus Time after an IV Bolus - Two compartment model

Equation 30.1.2 α plus β

Equation 30.1.3 α times β

alpha or beta

Equation 30.1.4 α or β

Equation 30.1.5 A value

Equation 30.1.6 B value

Last update: Thu 19 Jan 2012 09:10:02 am

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