Equation 30.31 Drug Concentration, Cp, after IV bolus dose - Two compartment
| Time (hr) | Cp (mg/L) | ||
| 0.25 | 0.44 | ||
| 0.5 | 0.36 | ||
| 0.75 | 0.3 | ||
| 1 | 0.27 | ||
| 1.25 | 0.24 | ||
| 1.5 | 0.22 | ||
| 2 | 0.2 | ||
| 4 | 0.17 | ||
| 6 | 0.16 | ||
| 9 | 0.14 | ||
| 12 | 0.13 |
Equation 30.31 Drug Concentration, Cp, after IV bolus dose - Two compartment
The table above provides a set of data for you to analyze. Using these data you should be able to estimate the slow rate constant, the β rate constant. You can then calculate the residual as the difference between early observed drug concentration values and the extrapolated Cplate values. The plot of this residual on semi-log graph paper then provides an estimate of the faster rate constant, the α rate constant.
Estimate A, B, α and β. Does the ratio of α to β satisfy the requirement of the method of residuals?
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