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Boomer Non-Linear Regression Program
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Macintosh/UNIX Mac OS X Terminal versions
- Mac OS X Version 3.6.4 for macOS 13.2, as a signed, notarized, zipped installer package file containing boomer, cDAT, eOUT, and eBest. [4 Mar 2023]
To install, right click on boomer364.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. Compiled on my M1 computer so there may be an issue Intel Macs.
- Mac OS X Version 3.6.3 for macOS 12.5, as a signed, notarized, zipped installer package file containing boomer, cDAT, eOUT, and eBest. [6 Aug 2022]
To install, right click on boomer363.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed and notarized. Also, it seems to work OK on my M1 computer. Compiled on my M1 computer so there may be an issue Intel Macs.
- Fixed grid search > gnuplot option
- Changed gnuplot to output animated gif files
- Mac OS X Version 3.6.1 for macOS 12.3, as a signed, notarized, zipped installer package file containing boomer, cDAT, eOUT, and eBest. [8 May 2022]
To install, right click on boomer361.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed and notarized. Thanks FX, for the compiler installer and help with the notarizing. Most essential. Also, it seems to work OK on my M1 laptop.
- Should work with Monterey (Intel and M1) and Catalina (Intel)
- Mac OS X Version 3.6 for macOS 12.3, as a signed, notarized installer package file containing boomer, cDAT, eOUT, and eBest. [20 Apr 2022]
To install, right click on boomer36.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed and notarized. Thanks FX, for the compiler installer and help with the notarizing. Most essential. Also, it seems to work OK on my M1 laptop.
- Added Phoenix NLME data outfile, with prefix Ph
- Fixed parameters 34-42, 34 and 37 were incomplete, 40-42 are better defined as well, that is, work better.
Compiled using the gfortran using the installer at https://gcc.gnu.org/wiki/GFortranBinaries
- Mac OS X Version 3.4.7 as a signed installer package file containing boomer, cDAT, eOUT, and eBest. [15 Feb 2021]
To install, right click on boomer346.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed!!!
- Mac OS X Version 3.4.6 as a signed installer package file containing boomer, cDAT, eOUT, and eBest. [10 Oct 2019]
To install, right click on boomer346.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed!!!
- Mac OS X Version 3.4.5 as a signed installer package file containing boomer, cDAT, eOUT, and eBest. [12 May 2019]
To install, right click on boomer345.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed!!!
- Fix some Pmetrics output issues
- Mac OS X Version 3.4.4 as a signed installer package file containing boomer, cDAT, eOUT, and eBest. [24 Mar 2019]
To install, right click on boomer344.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed!!!
- Mac OS X Version 3.4.3 as a signed installer package file containing boomer, cDAT, eOUT, and eBest. [19 Jul 2018]
To install, right click on boomer343.pkg and click on Continue. Enter your admin name and password when requested. Continue to follow the installer instructions. When finished boomer, cDAT, eBest and eOUT will be installed in /usr/local/bin; libquadmath.0.dylib will be installed in /usr/local/gfortran/lib and BoomerManual.pdf will be installed in /Applications. This package is now signed!!!
- General bug fixes to avoid Segmentation fault and formatting issues
- Mac OS X Version 3.4.2 as a signed installer package file containing boomer, cDAT, eOUT, and eBest. [19 Jun 2018]
- Should no longer require installation of gfortran to avoid missing libquadmath.0.dylib error message.
- Now distributed as a signed installer package, enjoy.
Windows/DOS versions which run under Windows in a DOS/Command window
Windows users may find it easier to right click on the required link below, Save Target as ..., and unzip with Winzip or similar).
If you move the executable files to some suitable folder such as C:\Users\yourUserName\Documents and set the PATH variable you can access the programs from any folder where you have data or plan to store data.
From the folder containing boomer.exe, cDat.exe, eOUT.exe and eBest.exe type
copy *.exe C:\Users\yourUserName\Documents\*.exe
copy *.dll C:\Users\yourUserName\Documents\*.dll
Now change the PATH variable by adding this new location.
PATH=%PATH%;C:\Users\yourUserName\Documents;
where yourUserName is your user directory name.
Developed with Window 11
Windows version Version 3.6.3 [updated 6 Aug 2022]
- Fixed grid search > gnuplot option
- Changed gnuplot to output animated gif files
Windows version Version 3.6 [updated 24 Jul 2022]
- Recompiled and includes required dll file
- Minor UI Adjustment
- Fix some Pmetrics output issues
- Minor formatting fix
- Optimal sampling update
- Added Phoenix NLME data outfile, with prefix Ph
- Fixed parameters 34-42, 34 and 37 were incomplete, 40-42 are better defined as well, that is, work better.
Windows version Version 3.4.3 [25 Aug 2018] - for now the data files need to be in the folder with the executable files.
- Fixed parameter 23 F-dependence
- Added ability to read .txt (tab delimited) and .csv (comma delimited) files
- Added F-dependence to Dose
- Added output files in Pmetrics format
- Add gnuplot file(s) generation
- General bug fixes to avoid Segmentation fault and formatting issues
Windows version Version 3.3.7 [18 Jul 2011]
- Added terminal half-life after AUC calculation
Windows version Version 3.3.6a [24 May 2011]
- Bug-fix to Weibull function
- updated eBEST v1.02 to provide eBestP.OUT file
Windows version Version 3.3.3 [22 Dec 2006]
- added eBEST v1.0
- updated eOUT v1.0.2
Windows version Version 3.3.2 [17 Apr 2006]
- added include files for better cross platform development
- eOUT v1.0.2
- gfortran version (please let me know if you have any problems with these files - david@boomer.org)
Windows version Version 3.3.1 [13 Apr 2006]
- gfortran version (second try - please let me know if you have any problems with these files - david@boomer.org)
- with cDAT and eOUT
Windows version Version 3.3.1 [30 Mar 2006]
- still g77 version updated to v3.3.1
Windows version Version 3.2.0 [25 Feb 2006]
- added Exponentially random to uniform, normal and log normal random error for data or parameters
Windows version Version 3.1.9 [16 Feb 2006]
- fixed a bug that caused a segmentation error with more than 30 adjustable parameters ;-)
- added form feed to output
Windows version Version 3.1.8 [24 Dec 2005]
- added Four parameter logistic model
- added AICc to the output table
Windows version Version 3.1.7 [30 Oct 2005]
- added output of sensitivity or optimal sampling analysis
- made output of xxx.htm,xxx.csv, and xxx.mdl optional
- still under development - watch the release date
Windows version Version 3.1.6 [27 Sep 2005]
- Added ME, MAE, RMSE and RMSE% to the output tables
Windows/DOS version Version 3.1.5 [10 Jul 2005]
- Added ability to read and write model data
Windows/DOS version Version 3.1.4 [6 Feb 2005]
- Fixed a few bugs related to writing *.htm and *.csv files
Windows/DOS version Version 3.1.3 [16 Dec 2004]
- Added x ** y to double dependence for parameters
Windows/DOS version Version 3.1.2 [1 Dec 2004]
- Added wt to xxx.csv and xxx.html files
Windows/DOS version Version 3.1.1 [26 Oct 2004]
- Ask to overwrite xxx.csv or xxx.html files
Windows/DOS version Version 3.1 [23 Oct 2004]
- Added data output as data.csv table file for Excel
- Added data output as data.html table file for Open Office rather rough for now
- Added Johannes Proost's equations for r and r^2 (both versions)
- Removed formfeed from print output
- Now using g77 to compile the program which is now comparable to Mac/Unix version re number of data, parameters and constants. See notes above for extra capability with this version
- Removed formfeed from print output
- Fix problem with quiet mode via web. That is, output goes to console unless to out file even in quiet mode
- Added entry of -5 for Monte Carlo number, restrict mc to < 100000
- Changed formulas for R^2, SC and LL
- Added entry of -4 and bat file name from keyboard
- Third argument is the number of runs - multi run with same bat file name
- Added call system to run gnuplot automatically after grid run
- Added command line argument for bat file, first argument is the name of the bat file and the second argument is '3' if quiet mode
- Added command line argument for bat and out file
- Allowed user to include extension during filename input
- Added () around c(calc(1)) when c(obs(1)) = 0 in AUC table
- Fix bug with WResid plot - oops - thanks Yung-jin
- Changed WResid plot versus Cp to WResid plot versus ln (Cp)
- Added log likelihood and Schwarz Criterion to the output
- Added the ability to clone components - useful for Sheiner PK/PD models
Appendix I - Sample .BAT (Macintosh format) or Sample .BAT (Zipped) format) files
Macintosh users should be able to download the .BAT files below by clicking on the link. Windows users may need to right click on the link and Save Target as.
Material on this website should be used for Educational or Self-Study Purposes Only
iBook and pdf versions of this material and other PK material is available
Copyright © 2001-2020 David W. A. Bourne (david@boomer.org)
Privacy Statement - 25 May 2018
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