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Example Calculations:

1. After a dose of 500 mg, V = 30 liter, kel = 0.2 hr-1

The following plasma concentrations can be calculated

Cp = Cp0 * e- kel * t

Thus:

Cp0 = 500/30 = 16.7 mg/liter Cp2 hours = 11.2 mg/liter

Cp4 hours = 7.5 mg/liter

Enter values into each field:
IV Bolus Dose:
Apparent Volume of Distribution: Cannot be zero
Elimination Rate Constant:
Time since IV Dose:

The answer Cpt is:

If you get the Error Message Value is not a numeric literal or NaN this probably means that one of the required parameter fields is empty or a value is inappropriate.

This page was last modified: 12 February 2001

Copyright 2001 David W.A. Bourne

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