2. We can also calculate the pharmacokinetic parameters kel and V if we know the dose given and the plasma concentrations at two (or more) times after an I.V. bolus administration. This time we could use the equation:

ln Cp = ln Cp^{0} - kel*t

If Cp^{2 hours} = 4.5 mg/liter and Cp^{6 hours} = 3.7 mg/liter after a 400 mg I.V. bolus dose then:

= - 0.0489 hr^{- 1}

thus kel = 0.0489 hr^{- 1}

Now ln Cp^{ 2 hr} = ln Cp^{0} - kel * t

ln 4.5 = ln Cp^{0} - 0.0489 x 2

ln Cp^{0} = 1.504 + 0.098 = 1.602

This page was last modified: 12 February 2001

Copyright 2001 David W.A. Bourne