3. Given kel (= 0.17 hr- 1) and V = (25 L) for a given drug we can calculate the dose required, by rapid IV bolus, to achieve a plasma concentration of 2.4 ug/ml (= 2.4 mg/L) at 6 hours.
Thus Cp6 = Cp0 * e- kel.t
Substituting in the values we know.
or 2.4 x 25 = DOSE * e- 1.02 = DOSE x 0.36
CHECK the UNITS
Copyright 2001 David W.A. Bourne