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Example Calculations:

3. Given kel (= 0.17 hr- 1) and V = (25 L) for a given drug we can calculate the dose required, by rapid IV bolus, to achieve a plasma concentration of 2.4 ug/ml (= 2.4 mg/L) at 6 hours.

Thus Cp6 = Cp0 * e- kel.t

Substituting in the values we know.

or 2.4 x 25 = DOSE * e- 1.02 = DOSE x 0.36

CHECK the UNITS


Enter values into each field:
Elimination rate constant:
Apparent Volume of Distribution: Cannot be zero
Keep Cp above:
for how long:

Cp0 is:
and required Dose is:

If you get the Error Message Value is not a numeric literal or NaN this probably means that one of the required parameter fields is empty or a value is inappropriate.

This page was last modified: 12 February 2001

Copyright 2001 David W.A. Bourne


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