PHAR 4634 - Chapter 4 Page 9

Example Calculations:

3. Given kel (= 0.17 hr^{- 1}) and V = (25 L) for a given drug we can calculate the dose required, by rapid IV bolus, to achieve a plasma concentration of 2.4 ug/ml (= 2.4 mg/L) at 6 hours.

Thus Cp⁶ = Cp⁰ * e^{- kel.t}

Substituting in the values we know.

or 2.4 x 25 = DOSE * e^{- 1.02} = DOSE x 0.36

CHECK the UNITS

This page was last modified: 12 February 2001

Elimination rate constant:
Apparent Volume of Distribution:		Cannot be zero
Keep Cp above:
for how long:

Cp⁰ is:
and required Dose is: