2. Given the data in Table, calculate kel, and V. Assume a one compartment linear model.
|Time Since Start of Infusion (hr)||Concentration (mg/L)|
3. A given drug follows linear one compartment pharmacokinetics. If the drug half-life is 7 hr and the apparent volume of distribution is 25 L, calculate the i.v. infusion necessary to achieve a steady state concentration of 25 mg/L (1). What i.v. bolus loading dose would you use to achieve 25 mg/L more rapidly (2)? What rapid i.v. infusion rate would you need to get to 25 mg/L in 30 minute (3)? Describe all three dosing regimen and sketch (not graph) the three plasma concentration versus time profiles.