PHAR 4634 Pharmaceutics III
Chapter 8
Homework Assignment - 1995 #4
1. Assuming a one compartment linear pharmacokinetic model, with kel = 0.14 hr-1; ka = 1.1 hr-1; F = 0.95; and V = 21.8 L, calculate the plasma concentration at 0.5, 1, 1.5, 2, 4, 6, 9, and 12 hours after a 250 mg oral dose. Plot the data on linear and semi-log graph paper.
Answer
2. Given the data in Table 1 and 2, calculate ka, F, kel, and V. Assume a one compartment linear model.
Table 1. Plasma Concentrations Measured after a 100 mg I.V. Bolus Dose of Drug X to Subject Y
| Time (hr)
| Concentration (mg/L)
|
| 1
| 5.72
|
| 3
| 4.14
|
| 6
| 2.56
|
Table 2. Plasma Concentrations Measured after a 300 mg Oral Dose of Drug X to Subject Y
| Time (hr)
| Concentration (mg/L)
|
| 0.25
| 2.28
|
| 0.5
| 4.33
|
| 0.75
| 5.67
|
| 1
| 6.89
|
| 1.5
| 8.81
|
| 2
| 9.31
|
| 3
| 9.68
|
| 4
| 10.25
|
| 6
| 7.51
|
| 9
| 4.98
|
| 12
| 3.25
|
Answer