PHAR 4634 Pharmaceutics III
Chapter 8
Homework Assignment  1995 #4
1. Assuming a one compartment linear pharmacokinetic model, with kel = 0.14 hr^{1}; ka = 1.1 hr^{1}; F = 0.95; and V = 21.8 L, calculate the plasma concentration at 0.5, 1, 1.5, 2, 4, 6, 9, and 12 hours after a 250 mg oral dose. Plot the data on linear and semilog graph paper.
Answer
2. Given the data in Table 1 and 2, calculate ka, F, kel, and V. Assume a one compartment linear model.
Table 1. Plasma Concentrations Measured after a 100 mg I.V. Bolus Dose of Drug X to Subject Y
Time (hr)
 Concentration (mg/L)

1
 5.72

3
 4.14

6
 2.56

Table 2. Plasma Concentrations Measured after a 300 mg Oral Dose of Drug X to Subject Y
Time (hr)
 Concentration (mg/L)

0.25
 2.28

0.5
 4.33

0.75
 5.67

1
 6.89

1.5
 8.81

2
 9.31

3
 9.68

4
 10.25

6
 7.51

9
 4.98

12
 3.25

Answer