Diagram XIV-3 Scheme for Oral Administration
Equation XIV-9 Rate of Change of Cp
Equation XIV-10 Cp versus Time
Figure XIV-5 Linear Plot of Cp versus Time
Figure XIV-6 Semi-log Plot of Cp versus Time
Aspirin given for a headache may be given as a single administration, whereas aspirin for arthritis will be given as a multiple dose. Antibiotics are usually given as a multiple dose regimen to produce and maintain effective plasma concentration. In fact, many drugs are given this way; anti-hypertensives, anti-epileptics etc.
Multiple dose administration is a very common method of drug administration. Up to this point we can calculate the drug concentration in plasma at any time after a single dose, we will continue now by looking at the equations for multiple dose administration.
Copyright 2001 David W.A. Bourne