Diagram XIX-1 Two Compartment Pharmacokinetic Model
Equation XIX-1 Differential Equation for the Central Compartment
The kel * X1 term describes elimination of the drug from the central compartment, while the k12 * X1 and k21 * X2 terms describe the distribution of drug between the central and peripheral compartments.
Cp = A * e- * t + B * e- * t with > .
The A, B, , and terms were derived from the microconstants during the integration process. They are functions of the microconstant k12, k21, kel and V1
+ = kel + k12 + k21
* = kel * k21