1. Assuming a two compartment linear pharmacokinetic model, with kel = 0.20 hr-1, k12 = 1.2 hr-1, k21 = 1.4 hr-1; and V = 43.8 L, calculate the plasma concentration at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12 hours after 100 mg i.v. bolus dose. Plot the data on linear and semi-log graph paper.
2. The data shown at the right were collected after an iv bolus of 200 mg.
Using the method of residuals calculate A, B,
,
and
.
Then calculate kel, k12, k21, Vc, and Varea.
Time (hr) | Concentration (mg/L) |
---|---|
0.25 | 14.8 |
0.5 | 12.1 |
1 | 8.8 |
2 | 6.0 |
4 | 4.0 |
6 | 2.2 |
8 | 1.4 |
10 | 0.91 |
12 | 0.55 |
3. Given that b = 0.14 hr-1 and Varea = 32.8 L calculate an oral dosing regimen to achieve an average plasma concentration of 15 mg/L (Assume F = 0.85).
4. A drug was administered both IV (200 mg) and PO (500 mg) to the same subject. The AUC and AUMC from the IV data were 87.5 mg.hr.L-1 and 745 mg.hr2.L-1, respectively. The AUC and AUMC from the PO data were 116.74 mg.hr.L-1 and 1095 mg.hr2.L-1, respectively. Using non compartmental methods calculate all appropriate pharmacokinetic parameters.