# Pharmaceutics III - PHAR 4634

## Homework #6

Not to be Graded
1. Assuming a two compartment linear pharmacokinetic model, with kel = 0.20 hr^{-1},
k12 = 1.2 hr^{-1}, k21 = 1.4 hr^{-1}; and V = 43.8 L,
calculate the plasma concentration at
0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12 hours after 100 mg i.v. bolus dose.
Plot the data on linear and semi-log graph paper.

Answer

2. The data shown at the right were collected after an iv bolus of 200 mg.
Using the method of residuals calculate A, B,
,
and .
Then calculate kel, k12, k21, Vc, and Varea.

Time (hr) |
Concentration (mg/L) |

0.25 |
14.8 |

0.5 |
12.1 |

1 |
8.8 |

2 |
6.0 |

4 |
4.0 |

6 |
2.2 |

8 |
1.4 |

10 |
0.91 |

12 |
0.55 |

Answer

3. Given that b = 0.14 hr^{-1} and Varea = 32.8 L calculate
an oral dosing regimen to
achieve an average plasma concentration of 15 mg/L (Assume F = 0.85).

Answer

4. A drug was administered both IV (200 mg) and PO (500 mg) to the same subject.
The AUC and AUMC from the IV data were 87.5 mg.hr.L^{-1} and 745 mg.hr^{2}.L^{-1}, respectively.
The AUC and AUMC from the PO data were 116.74 mg.hr.L^{-1} and 1095 mg.hr^{2}.L^{-1}, respectively.
Using non compartmental methods calculate all appropriate pharmacokinetic parameters.

Answer