Question 1
Given the data in Table 1 and 2, calculate ka, F, kel, and V using graph paper and calculator. Assume a one compartment linear model.












Table 2
Plasma Concentration after an Oral Dose of 450 mg
Time (hr) 
Cp (mg/L) 
0 

0.25 
0.6 
0.5 
1.1 
0.75 
1.5 
1 
1.9 
1.5 
2.5 
2 
2.8 
3 
3.2 
4 
3.2 
6 
2.8 
9 
1.9 
12 
1.3 
° 

Question 2.
Use a nonlinear regresion program to fit both the IV and oral data from question 1 simultaneously.
Question 3.
Given the model in Figure 1 and the data in Table 3 determine which of the parameters of this model are identifiable. Use either the numerical / empical approach and/or the analytical / Laplace transform approach. [Some additional information: The parameter values that I used to generate the data below are ke = 0.1 hr^{1}, km1 = 0.05 hr^{1}, km2 = 0.1 hr^{1}, and V1 = 20 L.]
Table 3
Plasma Concentration after an IV Bolus Dose of 200 mg
(hr) 

(hr) 
































