Chapter 9 Calculation of Bioavailability Parameters

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Bioavailability Calculations

Student Objectives for this Chapter

After completing the material in this chapter each student should:-

be able to calculate ka using
- the method of Residuals including
  - drawing the Cp^late line
  - estimating the residual values
  - drawing the residual line (and possibly rescaling the time axis)
- the method of Wagner and Nelson
- the method of Inspection
and describe when each method may be most appropriate
be able to calculate F using plasma (AUC) or urine (U^∞) data
understand the difference between absolute and relative bioavailability and be able to convert between these values

On many occasions you will be able to get the parameter values from tables and references. However, you should also know how to get these values from the data. The two parameters we will concentrate on in this Chapter are ka and F. These values can be used to compare dosage forms or brands. In Chapter 8 we saw the effect changing ka or F has on the plasma concentration time curve. In this chapter we will calculate ka and F from drug concentration versus time data.

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