Boomer Manual and Download | ||||

PharmPK Listserv and other PK Resources | ||||

Previous Page | Course Index | Next Page |

The Rules

- Reflect the point with the highest WSS through centroid (center) of the simplex
- If this produces the lowest WSS (best point) expand the simplex and reflect further
- If this is just a good point start at the top and reflect again
- If this the highest WSS (worst point) compress the simplex and reflect closer

**Figure 11.6.1 Contour map of kel versus V showing probable Path of Simplex Method**

The simplex method is relatively robust and numerically less complicated but it can be inefficient (slow) for simple problems. This method is recommended as a starting point with Boomer. Actually the method I use most of the time involves starting with the simplex method and (automatically) continuing with the Damping-Gauss-Newton method. It seems work well much of the time.

This page was last modified: Tuesday, 24th Oct 2017 at 5:56 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2001-2021 David W. A. Bourne (david@boomer.org)