Chapter 13
Formulation Factors
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Sustained Release Dosage Forms
Another form of coating is enteric coated tablets which are coated
with a material which will dissolve in the intestine but remain
intact in the stomach. Polymeric acid compounds have been used for
this purpose with some success. This topic and the area of sustained
release products has been discussed in more detail in other courses.
Benefits
- for short half-life drugs, sustained release can mean less
frequent dosing and thus better compliance.
- reduce variations in plasma/blood levels for more consistent
result.
Problems
- More complicated formulation, may produce more erratic results. A sustained release product may contain a larger dose, i.e. the dose for two or three (or more) 'normal' dosing intervals. A failure of the controlled release mechanism may result in release of a large potentially toxic dose.
- more expensive technology
Types of products
- erosion tablets
- waxy matrix
- matrix erodes or drug leaches from matrix
- coated pellets
- different pellets (colors) have different release
properties
- coated ion exchange
- osmotic pump
- insoluble coat with small hole. Osmotic pressure pushes the
drug out at a controlled rate.
Results - reduced side effects
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