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Figure 19.2.1 Linear plot of Calculated and Observed Data versus Time
Note the systemic, significant deviations between the line labeled 'Calculated (1c)'. This line represents the 'best' fit to a one compartment model. The two compartment (2c) model represents a much better fit to the observed data.
Figure 19.2.2 Linear plot of Weighted Residual versus Time
A pattern in the weighted residual plot may indicate that the model used is too small. In the case of Figure 19.2.2 there is a definite 'U' or 'V' shape suggesting that a bigger model (with two more parameters) should be investigated. A diagonal line would suggest a model with one additional adjustable parameter could be useful.
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