Figure 14.2.1 A Diagram Illustrating a One Compartment Model - IV Bolus
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Figure 14.2.1 A Diagram Illustrating a One Compartment Model - IV Bolus
This model can be defined using both differential and integrated equations.
Equation 14.2.1 Differential Equation describing a One Compartment Model - IV Bolus
Equation 14.2.2 Integrated Equation describing a One Compartment Model - IV Bolus
or in clearance terms
Equation 14.2.3 Equations describing a One Compartment Model - IV Bolus
Figure 14.2.2 A Diagram Illustrating a One Compartment Model - IV Infusion
This model can be defined using both differential and integrated equations.
Equation 14.2.4 Differential Equation describing a One Compartment Model - IV Infusion
Equation 14.2.5 Integrated Equation describing a One Compartment Model - IV Infusion
Equation 14.2.6 Equation describing a One Compartment Model - IV Infusion
Equation 14.2.7 Differential Equation describing a One Compartment Model - IV Infusion
Equation 14.2.8 Integrated Equation describing a One Compartment Model - IV Infusion
Figure 14.2.3 A Diagram Illustrating a One Compartment Model - Oral
This model can be defined using both differential and integrated equations.
Equation 14.2.9 Differential Equation describing a One Compartment Model - Oral
Equation 14.2.10 Integrated Equation describing a One Compartment Model - Oral
After a single IV bolus dose drug concentrations appear with an exponential decline on linear graph paper and a straight line on semi-log graph paper. With an IV infusion of duration T there is a steady increase to CpT followed by an abrupt exponential decline in concentration. After a single oral administration the curve around the peak concentration is smoother.
Figure 14.2.4 Linear Plot of Drug Concentration versus Time
Figure 14.2.5 Semi-log Plot of Drug Concentration versus Time
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